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KMID : 0043320050280121376
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Archives of Pharmacal Research
2005 Volume.28 No. 12 p.1376 ~ p.1380
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Hepatoprotective Constituents of the Edible Brown Alga Ecklonia stolonifera on Tacrine-induced Cytotoxicity in Hep G2 Cells
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Kim Youn-Chul
An Ren-Bo
Yoon Na-Young
Nam Tak-Jeong
Choi Jae-Sue
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Abstract
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In this study, ethanolic extracts from 18 seaweed variants were assessed for hepatoprotective activity against tacrine-induced cytotoxicity in Hep G2 cells. Only one of these, Ecklonia stolonifera Okamura (Laminariaceae), a member of the brown algae, exhibited promising hepatoprotective activity. Bioassay-guided fractionation of the active ethyl acetate (EtOAc) soluble fraction obtained from the ethanolic extract of E. stolonifera, resulted in the isolation of several phlorotannins [phloroglucinol (1), eckstolonol (2), eckol (3), phlorofucofuroeckol A (4), and dieckol (5)]. Compounds 2 and 4 were determined to protect Hep G2 cells against the cytotoxic effects of tacrine, with values of 62.0 and 79.2 g/mL, respectively. Silybin, a well characterized hepatoprotective agent, was used as a positive control, and exhibited an value of 50.0 g/mL. It has been suggested that the phlorotannins derived from marine brown algae might prove useful sources in the development of novel hepatoprotective agents.
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KEYWORD
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Ecklonia stolonifera, Hepatoprotective, Phlorotannins, Marine algae, Tacrine, Hep G2 cells
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